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Poli

DNA polymerase iota is an enzyme that in humans is encoded by the POLI gene. It is found in higher eukaryotes, and is believed to have arisen from a gene duplication from Pol η. Pol ι, is a Y family polymerase that is involved in translesion synthesis. It can bypass 6-4 pyrimidine adducts and abasic sites and has a high frequency of wrong base incorporation. Like many other Y family polymerases Pol ι, has low processivity, a large DNA binding pocket and doesn't undergo conformational changes when DNA binds. These attributes are what allow Pol ι to carry out its task as a translesion polymerase. Pol ι only uses Hoogsteen base pairing, during DNA synthesis, it will add adenine opposite to thymine in the syn conformation and can add both cytosine and thymine in … more »

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 Become A Better Singer In Only 30 Days, With Easy Video Lessons!

Do you feel blue
You need some help
And after all the things you’ve done 
You’re still trying to figure out 
Where are you
Are you still waiting
And if you’re feeling so alive
Then tell us everything on your mind 

Ya come on over, saying how you think it’s gotta be 
Telling people what ideas you have got for me

I know what I’m thinking, I know what I’m bringing
The only thing I’m speaking is the crux of it 
Color up my lips, working hard for tips
Baby, when I’m coming home all I do is take it off
I check my face and play it off

Reading everything on my mind
 
They say that you need a reason
For every move you make 
They say that you need to sprint
But I gotta catch a break 

They say that you need a reason
For every move you make 
They say that you need to sprint
But I gotta catch a break 
‘Cause I don’t wanna waste my time being under pressure

The stars are bright enough to conquer on my own 

Don’t need to look for me
Look for yourself

And after all the things I’ve done
You’re still trying to help me out 
Free to roam

That’s not the life you’ve known 
But look how I’ve grown 
I’m alive and I’m on my own 

Ooh, gonna be on my own 
Aah, gonna be on my own 
Ooh, yeah

They say that you need a reason
For every move you make (Every move you make)
They say that you need to sprint
But I gotta catch a break 

They say that you need a reason
For every move you make (Every move you make)
They say that you need to sprint
But I gotta catch a break 
‘Cause I don’t wanna waste my time being under pressure

The stars are bright enough to conquer on my own 

They say that you need a reason
For every move you make (Every move you make)
They say that you need to sprint
But I gotta catch a break 
‘Cause I don’t wanna waste my time being under pressure

The stars are bright enough to conquer on my own

 Become A Better Singer In Only 30 Days, With Easy Video Lessons!