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Motilin receptor is a G protein-coupled receptor (previously GPCR38) that binds motilin. It was first cloned in 1999 by Merck Laboratories. and scientists have since been searching for compounds to modify its behavior.The primary structure of the motilin receptor consists of 412 amino acids, while its tertiary structure resembles a golf club. The protein C-terminal protein protects from enzymatic degradation, while the N-terminal is essential for binding.

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