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Deficiency of the interleukin-1–receptor antagonist (DIRA) is an autosomal recessive, genetic autoinflammatory syndrome resulting from mutations in IL1RN, the gene encoding the interleukin 1 receptor antagonist. The mutations result in an abnormal protein that is not secreted, exposing the cells to unopposed interleukin 1 activity. This results in sterile multifocal osteomyelitis, periostitis (inflammation of the membrane surrounding the bones), and pustulosis due to skin inflammation from birth.
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Albums by DIRASort:By AlbumA - Z
Unknown Album
Song | Duration |
---|---|
Far Away | |
Jakarta Dreams [In support of the Roslin Orphanage in West Timor Indonesia] | 5:34 |
Kisahku Masa Lalu | 4:30 |
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